Very excited to announce our latest mini-review/commentary article where we discuss the latest breakthroughs in the mechanism of Platinum chemotherapy resistance in Lung Adenocarcinoma. You can access the full article here for free [Link] You can also vote for our graphical abstract here in the BioRender art competion
We are very excited to announce the publishing of "A Compendium to the Phosphoregulation of Mitosis" on the open access repository Zenodo. This compendium accompanies the 2017 publication in Cell and the interactive website. In the compendium, we have compiled all the text from the 88 popups in the online interactive visualization, with the aim of making this information more…
I am very excited to announce our new review paper which is out now in Front Cell Dev Biol [Link]. This is also the first paper from Dr Kamila Marzec who recently joined the lab. Great work! MASTL kinase is a master regulator of mitosis, essential for ensuring that mitotic substrate phosphorylation is correctly maintained. It achieves this through the phosphorylation…
More great news, we have another co-author publication in the outstanding journal Gut. This fabulous work was pioneered by the very talented Dr Marina Pajic and her group at the Garvan Institute. We were very honoured to be involved in such amazing work. The title of the publication is "Tailored first-line and second-line CDK4-targeting treatment combinations in mouse models of…
Great news, we have published a co-authored paper entitled 'Ensa controls S-phase length by modulating Treslin levels' in the prestigious journal 'Nature Communications'. This work was started back in 2011 when I was a Post-Doc in the laboratory of Anna Castro in France. It's exciting to see those inital discoveries transition into the finished paper. The article is Open Access and…
We are incredibly excited to announce that our SnapShot is out today in Cell! This snapshot of mitosis collates hundreds of phosphorylation events and directly links them with their regulatory kinases and counterbalancing phosphatases, in both time and space, in a highly innovative 'circtanglar' cell layout. More importantly, the static PDF version is accompanied by an interactive website that enables users…
8th Garvan Signalling Symposium Date: Monday 31st of October and Tuesday 1st of November 2016 Venue: The Garvan Institute of Medical Research, Sydney Registration - Abstract submission to 15th of September 2016 The Garvan International Signalling Symposium is a premier meeting focused on the mechanisms of signal transduction. It began as a small meeting organised by Prof. Roger Daly around the…
Great News, our review on how phosphatase specificity is controlled during mitosis has been re-published in BioEssays and is now Online! This review was originally published in Inside the Cell, which unfortunately has shut down. But the good news is that it is still Open Access, so that means its free for everyone to read! And is now also indexed in…
A defining feature in over 2/3rds of all solid tumours is the continual loss and gain of whole are small parts of chromosomes. This instability, or CIN for short, strongly implicated in tumour initiation, progression, chemoresistance and poor prognosis. CIN is created through failures during mitosis, whereby whole or parts of a chromosome are segregated incorrectly, thereby created daughter cells…
Great news, we have a new Mini-Review published in Frontiers Oncology entitled "Clinical Overview of MDM2/X-Targeted Therapies", which is apart of the Research Topic Human tumor-derived p53 mutants: a growing family of oncoproteins Here is a little snippet from the Abstract to wet your appetite! MDM2 and MDMX are the primary negative regulators of p53, which under normal conditions maintain low intracellular…