Updates on what is happening.
Great news, we have a new Mini-Review published in Frontiers Oncology entitled "Clinical Overview of MDM2/X-Targeted Therapies", which is apart of the Research Topic Human tumor-derived p53 mutants: a growing family of oncoproteins Here is a little snippet from the Abstract to wet your appetite! MDM2 and MDMX are the primary negative regulators of p53, which under normal conditions maintain low intracellular…
Its no secrete that Funding for Science in Australia, and around the world (see refs below), is in decline. The result is lower and lower success rates. While we wait for the #NHMRC to release the outcomes for 2015, the word on the street is that we can expect only 10-12% of grants to be successful. In other words,…
A recent high profile publication in Science Translational Medicine proposed that antioxidants might increase the rate of metastasis in mice models of melanoma. NAC and the soluble vitamin E analog Trolox markedly increased the migration and invasive properties of human malignant melanoma cells but did not affect their proliferation. Both antioxidants increased the ratio between reduced and oxidized glutathione in…
Great News, we have a new review article that has just been published online today in Inside the Cell! Its Open Access, so that means its free for everyone to read! During mitotic exit, phosphatases reverse thousands of phosphorylation events in a specific temporal order to ensure that cell division occurs correctly. This review explores how the physicochemical properties of the…
Great news we are currently looking for a new honours student for 2016. The title of the project is "Developing novel biosensors to monitor DNA damage in cancer cells". Its a very exciting new project incorporating cutting edge microscopy and fluorescent biosensors. If you think you have what it takes and are interested please feel free contact myself, or UNSW…
Great news, we have another publication. This time its some extra data left over from our large mass spectrometry study we published in August in Molecular & Cellular Proteomics. This latest work we provide additional analysis of our large proteomics dataset and identify motifs that correlated strongly with phosphorylation status for each of the major mitotic kinases. These motifs could be used to predict…
Great news our recent paper "Global phosphoproteomic mapping of early mitotic exit in human cells identifies novel substrate dephosphorylation motifs., Molecular & Cellular Proteomics, 2015 (DOI: 10.3410/f.725545508.793507630), has been recommended in F1000Prime as being of special significance in its field by F1000 Faculty Member Angus Nairn. Really glad to see that all our hard work and research is being found useful…
Great news our latest publication "Global phosphoproteomic mapping of early mitotic exit in human cells identifies novel substrate dephosphorylation motifs" has been accepted by the top Proteomics Journal Molecular & Cellular Proteomics. You can currently download the unformatted version for free here [link] And here is an still image from the paper showing live HeLa cells undergoing forced phosphatase dependent…
Hi everyone, I am honoured to have recently joined the National board of directors of the Australian Society for Medical Research (#ASMR). This is a fantastic society that has for decades fought for a better working environment and more sustainable investment in Medical research. We recently launched a campaigned to help restore much needed funding to the sector, which as…
I am pleased and honoured to announce that I recently joined the ASMR (Australian Society for Medical Research) National Board of Directors, and have taken on the Newsletter portfolio. With that said, I am very proud to announce that the latest ASMR newsletter is now available on-line for FREE ! You can download and view it here There are some…