Updates on what is happening.
I am very excited to announce our new review paper which is out now in Front Cell Dev Biol [Link]. This is also the first paper from Dr Kamila Marzec who recently joined the lab. Great work! MASTL kinase is a master regulator of mitosis, essential for ensuring that mitotic substrate phosphorylation is correctly maintained. It achieves this through the phosphorylation…
Very exciting day to see this amazing work by the lab of Prof.Neil Watkins published in the prestigious Science Translational Medicine Journal. A huge amount of work for a lot of very talented people over many many years went into this study, and hopefully it will result in significant improvements for the treatment of lung cancer patients using platinum based…
Great news, we have recently published a co-author paper in collaboration with Darren Saunders Lab entitled "The E3 ubiquitin ligase UBR5 regulates centriolar satellite stability and primary cilia". The work was pioneered by a very talented student (now Doctor), Robert Shearer. You can access the full article here [Link] ABSTRACT Primary cilia are crucial for signal transduction in a…
Very excited to announce that our latest paper entitled "MASTL overexpression promotes chromosome instability and metastasis in breast cancer" has just been published online with Oncogene. You can access the full article for free here:https://www.nature.com/articles/s41388-018-0295-z Abstract MASTL kinase is essential for correct progression through mitosis, with loss of MASTL causing chromosome segregation errors, mitotic collapse and failure of cytokinesis. However,…
Great news, we are looking for a full-time research assistant or junior post-doctoral researcher. We are seeking a highly motivated BSc (Hons) graduate who is interested in pursuing a career in biomedical research with particular focus on cancer cell biology. The successful applicant will have demonstrated a high level of undergraduate achievement and applicants graduating with Honours will be highly regarded.…
Great news, we have a new co-author publication out in the journal Oncogene! The work was lead by Professor Neil Watkins, and is titled "The tumor suppressor Hic1 maintains chromosomal stability independent of Tp53". You can access the full article here [Link] ABSTRACT: Hypermethylated-in-Cancer 1 (Hic1) is a tumor suppressor gene frequently inactivated by epigenetic silencing and loss-of- heterozygosity in…
More great news, we have another co-author publication in the outstanding journal Gut. This fabulous work was pioneered by the very talented Dr Marina Pajic and her group at the Garvan Institute. We were very honoured to be involved in such amazing work. The title of the publication is "Tailored first-line and second-line CDK4-targeting treatment combinations in mouse models of…
Great news, we have published a co-authored paper entitled 'Ensa controls S-phase length by modulating Treslin levels' in the prestigious journal 'Nature Communications'. This work was started back in 2011 when I was a Post-Doc in the laboratory of Anna Castro in France. It's exciting to see those inital discoveries transition into the finished paper. The article is Open Access and…
We are incredibly excited to announce that our SnapShot is out today in Cell! This snapshot of mitosis collates hundreds of phosphorylation events and directly links them with their regulatory kinases and counterbalancing phosphatases, in both time and space, in a highly innovative 'circtanglar' cell layout. More importantly, the static PDF version is accompanied by an interactive website that enables users…